Select Publications

2024

Hilt ZT, Charles W, Ali T, Smith CV, Zhang S, Wesnak SP, Smith NL, Rudd BD.  Cutting Edge: Reinoic Acid Promotes Brain-homing of CD8+ T cells during Congenital Cytomegalovirus Infection.  Journal of Immunology.  Aug 12.

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Yee Mon KJ, Kim S, Dai Z, West JD, Zhu H, Jain R, Grimson A, Rudd BD, Singh A. Functionalized nanowires for miRNA-mediated therapeutic programming of naive T cells.  Nature Nanotechnology. Aug; 19(8):1190-1202.

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Maymi VI, Zhu H, Jager M, Johnson S, Getchell R, Casey JW, Grenier JK, Wherry EJ, Smith NL, Grimson A, and Rudd BD.  Neonatal CD8+ T cells resist exhaustion during chronic infection.  Journal of Immunology.  Mar 1;212(5):834-843.

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Watson NB, Patel RK, Kean C, Veazey J, Oyesola OO, Laniewski N, Grenier JK, Wang J, Tabilas C, Yee Mon KJ, McNairn AJ, Peng SA, Wesnak SP, Nzingha K, Davenport MP, Tait Wojno ED, Scheible KM, Smith NL, Grimson A, Rudd BD.  The gene regulatory basis of bystander activation in CD8+ T cells.  Sci Immunol. 2024. Feb 23;9 (92)

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Imbiakha B, Sahler JM, Buchholz DW, Ezzatpour S, Jager M, Choi A, Monreal IA, Byun H, Adelke RA, Leach J, Whittaker G, Dewhurst S, Rudd BD, Aguilar HC, August A. Adaptive immune cells are necessary for SARS-CoV-2-induced pathology.  Sci Adv. 2024. Jan 5;10(1). PMID: 38170764.

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2023 

Tabilas C, Smith NL, Rudd BD. Shaping immunity for life: Layered development of CD8+ T cells. Immunol Rev. 2023 Jan 18. doi: 10.1111/imr.13185.

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Kim D, An L, Moon J, Maymi VI, McGurk AI, Rudd BD, Fowell DJ, White AC.  CCR2+ Monocyte-Derived Macrophages Influence Trajectories of Acquired Therapy Reistance in Braf-Mutant Melanoma. Cancer Res.  2023. doi: 10.1158/0008-5472.CAN-22-2841. PMID: 37195124

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2022

Tabilas C, Iu DS, Daly CWP, Yee Mon KJ, Reynaldi A, Wesnak SP, Grenier JK, Davenport MP, Smith NL, Grimson A, Rudd BD. ​Early microbial exposure shapes adult immunity by altering CD8+ T cell development. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2212548119. doi: 10.1073/pnas.2212548119. 

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Lee SE, Rudd BD, and Smith NL.  Fate-mapping mice: new tools and technology for immune discovery.  Trends of Immunology.  2022.  Mar; 43(3)195-209.

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Hilt Z, Charles W, Cheng K, Tabilas  C, Smith NL, Schaffer CB, Rudd BD. Cutting Edge: CCR9 promotes CD8+ T cell Recruitment to the Brain During Congenital CMV Infection. Journal of Immunology. Nov 2022. doi: 10.4049/jimmunol.2200578. PMID: 36344110

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2021

Yee Mon KJ, Zhu H, Daly CWP, Vu LT, Smith NL, Patel R, Topham DJ, Scheible K, Jambo K, Le MTN, Rudd BD, Grimson A.MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response. Cell Rep. 2021 Nov 9;37(6):109969. DOI: 10.1016/j.celrep.2021.109969

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2020

Davenport, MP, Smith, NL, Rudd, BD. Building a T cell compartment: how immune cell development shapes function. Nat Rev Immunol (2020). https://doi.org/10.1038/s41577-020-0332-3

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Rudd BD. Neonatal T Cells: A Reinterpretation. Annu. Rev. Immunol. 2020. 38:229–47 doi: https://doi.org/10.1146/annurev-immunol-091319-083608 

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2019

Tabilas C, Wang J, Liu X, Locasale JW, Smith NL, Rudd BD. Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life. J Immunol. 2019 Oct 9. pii: ji1900426. doi: 10.4049/jimmunol.1900426.

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Yee Mon KJ, Goldsmith E, Watson NB, Wang J, Smith NL, Rudd BD. Differential Sensitivity to IL-12 Drives Sex-Specific Differences in the CD8+ T Cell Response to Infection. ImmunoHorizons. April 1, 2019, 3 (4) 121-132

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Reynaldi A, Smith NL, Schlub TE, Tabilas C, Venturi V, Rudd BD, Davenport MP. Fate mapping reveals the age structure of the peripheral T cell comparment.  Proc Natl Acad Sci U S A.  2019 Feb 14. pii: 201811634. https://doi: 10.1073/pnas.1811634116.

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2018

Smith NL, Patel RK, Reynaldi A, et al. Developmental Origin Governs CD8 T Cell Fate Decisions during Infection. Cell. 2018;174(1):117-130.e14.

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2016

Wang J, Wissink EM, Watson NB, Smith NL, Grimson A, Rudd BD. Fetal and adult progenitors give rise to unique populations of CD8+ T cells. Blood. 2016;128(26):3073-3082.

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Reynaldi A, Smith NL, Schlub TE, Venturi V, Rudd BD, Davenport MP. Modeling the dynamics of neonatal CD8(+) T-cell responses. Immunol Cell Biol. 2016;94(9):838-848.

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Venturi V, Nzingha K, Amos TG, et al. The Neonatal CD8+ T Cell Repertoire Rapidly Diversifies during Persistent Viral Infection. J Immunol. 2016;196(4):1604-16.

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2015

Smith NL, Wissink EM, Grimson A, Rudd BD. miR-150 Regulates Differentiation and Cytolytic Effector Function in CD8+ T cells. Sci Rep. 2015;5:16399.

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Wissink EM, Smith NL, Spektor R, Rudd BD, Grimson A. MicroRNAs and Their Targets Are Differentially Regulated in Adult and Neonatal Mouse CD8+ T Cells. Genetics. 2015;201(3):1017-30.

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Cohen SB, Smith NL, Mcdougal C, et al. Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells. J Immunol. 2015;194(1):210-22.

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2014

Smith NL, Wissink E, Wang J, et al. Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life. J Immunol. 2014;193(1):177-84.